Abstract
SYNTHESIS AND ANTICONVULSANT STUDIES OF SOME NEWER BENZOTHIAZEPINE DERIVATIVES

K. Srinivasa Rao*, M. Sai Bharath, K. Rajini Kathn, V. Venkata Rao and N. Rama Rao

ABSTRACT

The 1,5-benzothiazepines are important nitrogen and sulfur-containing seven-membered heterocyclic compounds in drug research because they posess diverse bioactivities. The 1, 5- benzothiazepine derivatives are of particular interest for lead discovery because they have been found to be active against different sites of targets. Benzothiazepine and its derivatives found to exhibit diverse biological activities such as coronary tranquilizer, anticovulsant activity,antidepressant, antihypertensive, calcium channel blocker. Benzothiazepine derivatives wereprepared by using Chalcones in presence of o-aminothiophenol. The synthesized compoundswere characterized by using IR –Spectral. Maximal electroshock seizure (MEC) method was used for the pharmacological evaluation of synthesized 1,5- Benzothazepine derivatives .

Keywords: Benzothiazepine, o-aminothiophenol Maximal electroshock seizure, anticonvulsant activity, antihypertensive.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT