Abstract
IMMUNOMODULATORY EFFECT OF FLAVONOID FROM MUSA PARADISIACA ON HUMAN WHOLE BLOOD AGAINST SPECIFIC PROTEIN ANTIGEN

Abhijit B. Powar, Amit Gupta*, Sanjay Kamble and Bharat Shinde

ABSTRACT

Objective- The objective of our study is to investigate its immunomodulatory properties of flavonoid isolated from peels of Musa paradisiaca. Methods- Immunological activities of flavonoid were evaluated on human whole blood against specific protein (rubella vaccine) antigen using various assays i.e. Elisa, proliferation and total cellular content. Results- In this study, flavonoids isolated from peel powder of Musa paradisiaca and determined its immunomodulatory potential against rubella vaccine antigen. The results showed that these flavonoids showed dose dependent increased in antibody titre at higher doses as compared to control. In addition, these flavonoids also showed enhancement in proliferation assay and total cellular content at lower doses. Conclusion- Overall, the results of the present study indicate that the flavonoid isolated from the peels of Musa paradisiaca having potent immunomodulatory activities.

Keywords: Musa paradisiaca; flavonoid; antibody; proliferation; cellular.


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