Abstract
HISTOPATHOLOGICAL STUDIES OF METHANOL EXTRACT OF CORIANDRUM SATIVUM LINN FRUIT ON STREPTOZOTOCINE INDUCED DIABETIC RAT

M. Padmaa Paarakh*

ABSTRACT

The present study was undertaken to evaluate the histopathological changes by 75% methanol extract of Coriandrum sativum Linn in streptozotocine induced diabetic rats which has been claimed to possess antidiabetic properties in Traditional System of Medicine. The streptozotocine induced albino rats were orally treated with vehicle[diabetic control], Glibenclamide (0.5 mg /kg; standard control) and 75% methanol extract [100 mg/kg and 200 mg/kg as CS1 and CS2] respectively for 14 days. Histopathological changes in the diabetic rat organ viz., heart, Kidney, liver and spleen were observed after 14 days of treatment. The 75% methanol extract showed significant decrease in blood glucose level at a dose of 100 mg/kg and 200 mg/kg. Histopathological changes are restored near to normal after treatment with CS1 and CS2. The results demonstrate that the fruit of C.sativum Linn possess significant antidiabetic activity in diabetic rats and possesses favourable effect on vital organ such as heart, Kidney, liver and spleen, thereby justifying the use of the plant as antidiabetic agent.

Keywords: Coriandrum sativum, Diabetes mellitus, Streptozotocine, Histopathology


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