Bhagyesh Milan Pendse* and Dr. Sujata Prahlad Sawarkar


Vitamin B12 (Cobalamin) is a vital micronutrient. Although, it is required in miniscule levels in the body, it performs many vital functions. It is found exclusively in animal sources with a very few plant sources available. Deficiency of Vitamin B12 is a very common cause for megaloblastic anaemia particularly affecting the elderly population and people on vegetarian diet. With very limited plant sources available, fortification of common food with Vitamin B12 supplements in form of Cyanocobalamin becomes the obvious choice for maintaining appropriate levels in vegetarian population to avoid deficiency. However, many challenges are posed when Vitamin B12 is given orally and intramuscularly. Thus, there is a continuous need for development of newer strategies to effectively deliver the appropriate levels of Vitamin B12. There are variety of causes for the deficiency which also includes certain drug induced causes. Many novel drug delivery strategies have been attempted to deliver cobalamin effectively viz. the sublingual route, intranasal route, transdermal route, and these drug delivery strategies have proven to give beneficial results in preclinical trials or in human subjects. This review article gives an overview of the sources, absorption, causes, chemistry, biochemistry, available treatments for deficiency and the recent methods that have evolved for mitigating the problem of Vitamin B12 deficiency.

Keywords: Vitamin B12, Cyanocobalamin, transdermal, perineural, nanoparticles, microemulsions

[Full Text Article]   [Download Certificate]


Forgot Password  |  Register


Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation


    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.


UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS


Copyright From

Covering Letter

                        Author Instruction