Abstract
INTRATHECAL MORPHINE FOR POSTOPERATIVE ANALGESIA IN POSTERIOR LUMBAR SPINE DECOMPRESSION AND INSTRUMENTATION: A COMPARATIVE STUDY OF TWO DIFFERENT DOSES.

Dr. Priyanka Dhir*

ABSTRACT

Background: Patients undergoing lumbar spine instrumentation surgery suffer severe postoperative pain which is difficult to treat by conventional multimodal analgesic methods. In this randomized double blind study we compared the analgesic effect of two different doses of intrathecal morphine (ITM) 0.2 mg and 0.3 mg in patients undergoing posterior lumbar spine decompression and instrumentation surgery. Materials and Methods: Forty ASA 1 and 2 patients of either sex aged 18 years or older undergoing posterior lumbar spine decompression and instrumentation surgery between L1-L5 were randomly assigned to receive ITM either 0.2 mg (Group A, n=20) or 0.3 mg (Group B, n=20) in 2 ml saline before general anaesthesia. A morphine intravenous patient controlled analgesia (PCA) device was used for rescue analgesia in postoperative period. Assessment parameters included hemodynamics, sedation score, pain using numeric rating scale (NRS), total consumption of PCA morphine recorded for 24 hours and patient‟s satisfaction score. The data was analyzed using chi square test for categorical variables and student‟s t test for quantitative variables. Result: NRS score was significantly low in group B at 4, 8, 12 and 24 hours as compared to group A (p < 0.05). Group B also had decreased requirement for rescue analgesia (p = 0.001) with higher patient satisfaction. There was no significant difference between the two groups in other studied parameters. Conclusion: 0.3 mg ITM provided superior analgesia postoperatively in terms of NRS score and higher patient satisfaction compared with 0.2 mg with no significant difference in the incidence of side effects.

Keywords: Morphine, Intrathecal, Spine surgery, Patient controlled analgesia.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT