European Journal of Biomedical and Pharmaceutical Sciences

“FORMULATION DEVELOPMENT OF FAST DISPERSIBLE TABLET OF CEFUROXIME AXETIL”

Vedang Pandya*, Harshal Sheth, Snehal Patel, Kartik Pandya and Chintan Aundhia

ABSTRACT

Cefuroxime Axetil is second generation cephalosporin and an orally active drug. Cefuroxime exerts its bactericidal effect by binding to the enzymes involved in bacterial cell wall synthesis. Cefuroxime Axetil is used for upper respiratory tract infection for treatment of sudden allergic attacks. The drug has poor solubility in water and bitter unpleasant taste. Solubility was enhanced with β- CD by Solid dispersion method, before that it was confirmed by Phase solubility study indicated (1:1 molar ratio) Suggested Al curve linearity with stability constant (416 M-1). Solubility of Cefuroxime axetil was comparatively evaluated with drug solubility without solubilising agent by shaking flask method which was increased. Afterwards Complexes were analysed by UV-VIS spectroscopy and characterized by infrared spectroscopy, DSC and XRPD which confirmed for complex formation. Almost 90% drug was released from the complexes within 60 min. These complex converted in to taste masked resinate by ion exchange resin using indion-235 (1:0.5) ratio with 59.30% drug content and then formulated Fast dispersible tablet by means of SSG (X 1) and Camphor (X 2) as an independent parameter using 3 2 full factorial design. % Friability (Y1) and DT (Y2) and % Drug release (Y3) were selected as dependent variables. A mathematical model was generated for each response parameter. As increase the concentration of SSG, DT was decrease and % Drug release was increased shown in result and discussion. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results.

Keywords: Cefuroxime Axetil, SSG, Camphor, ?- Cyclodextrin, Solid Dispersion & Fast Dispersible Tablet.