European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF AQUEOUS, ETHANOL AND ACETONE EXTRACT OF SESBANIA GRANDIFLORA IN GENTAMICIN - INDUCED NEPHROTOXIC RATS

K. Padmalochana* and M.S. Dhana Rajan

ABSTRACT

Phytotherapeutic medicine from medicinal plants has been greatly explored due to its bioactive secondary metabolites production, cost effective, cheaply available and no side effects.In this presentation we studied the nephroprotective effects of aqueous, ethanol and acetone extracts of medicinal plant Sesbania grandiflora leaves against gentamicin affected animals. Animals were grouped into six, each groups has six animals (Group I-normal, II- induced, III- standard drug, IV- aqueous extract, V- ethanol extract, VI- acetone extract). Drug and extracts were orally administered and measured urea, uric acid, creatinine and total protein in the control and treated groups. The animal groups I, II, and III shows increased levels of urea, uric acid and creatinine and decreased levels of protein (p<0.05) indicates gentamicin induced nephrotoxicity in rats. The animals treated with extracts has shown decreased levels (p<0.001) of urea, uric acid and creatinine and increased levels of protein in blood serum compared with controls (Group IV, V, and VI). Further the histopathological examinations also confirm the curative properties of extracts of Sesbania grandiflora leaves against nephrotoxicity. Gentamicin affected renal tissue shows severe necrosis and degeneration in tubular compared than control groups animals. These swelling and degenerated tissue in kidney was restored in extracts treated animal groups.

Keywords: Sesbania grandiflora, Kidney, Nephrotoxocity,