European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF METABOLIC SYNDROME IN TYPE 2 DIABETES MELLITUS

Chandrasekhar Valupadas*, Pavan Kumar Muttineni, Vasanth Kumar Suram, Chandana Naliganti

ABSTRACT

Background & Objectives: Metabolic syndrome is a cluster of the most dangerous cardiovascular risk factors namely diabetes, abdominal obesity, high cholesterol and elevated blood pressure. For defining metabolic syndrome, there are several criteria’s like AHA, EGIR, NCEP/ATP III, WHO and IDF. The present study was undertaken to understand the clinical profile and associated risk factors of metabolic syndrome in Type 2 Diabetes Mellitus (T2DM) patients based on WHO criteria. Methods: A prospective cohort study was conducted for a period of October 2012 to September 2013 in patients who are attending Out Patient Department (OPD) at Mahatma Gandhi Memorial Hospital, Warangal with T2DM according to WHO criteria. Two hundred T2DM patients were subjected to detailed history, clinical examination and biological investigations were conducted, data was collected, tabulated and interpretation was done. Results: Our study included 200 participants with Type 2 Diabetes mellitus for screening. The overall mean age of the study population was 53.68 ±8.8 years with range of (37-76) years. Out of 200 screened populations, a total of 152(76%) patients were identified with Metabolic Syndrome according to WHO (1999) criteria. Among 152, 108(71.05%) were males and 44(28.95%) were females. Metabolic syndrome was found to be more in male(77.14%) compared to female(73.33 %). The more common risk factors found in the study population were, low HDL-C(73.68%), high Triglycerides(57.89%), increased waist to hip ratio(52.63%) and elevated blood pressure(50.00%); microalbuminuria(13.16%) being the least common risk factor. Interpretation & Conclusion: This study proved that metabolic syndrome was found highly prevalent in T2DM patients using WHO criteria. Low level of HDL-C, high triglyceride levels, increased waist to hip ratio, hypertension and microalbuminuria are significantly associated with T2DM.

Keywords: Diabetes mellitus, Metabolic Syndrome, WHO criteria, NCEP/ ATP III criteria.