European Journal of Biomedical and Pharmaceutical Sciences

INHIBITION OF HLCA-549 CELL PROLIFERATION AND SURVIVAL BY ETHANOLIC EXTRACT OF PHALLUSIA NIGRA SAVIGNY, 1816

Manuelraj Paripooranaselvi*, Vaidyanathapuram Kesavan Meenakshi and Sudalaimuthu Gomathy

ABSTRACT

Lung cancer is one of the leading cancers affecting and reducing the life span of people in India, hence there is an urgent need for drug development. The present research article was aimed to study the antiproliferative property of the ethanolic extract of Phallusia nigra against HLCA-549 bearing adult Swiss albino mice. Cytotoxicity, relative organ weight, solid tumor volume, median survival time, increase of lifespan, packed cell volume, viable and non –viable cell count and hematological parameters were studied using the extract. The extract was 100% toxic at 0.80 mg/ml concentration. The results showed a dose dependent decrease in tumor volume, packed cell volume, viable cell count and an increase in non viable cell count and mean survival time there by increasing the life span by 67.77% in group IV treated with 150 mg/kg body weight of the extract. Administration of the extract resulted in an increase in Hb, WBC and lymphocytes whereas a decrease was noted in neutrophil and eosinophil count. The present study indicates that Phallusia nigra is a significant source of bioactive compounds with antiproliferative property against HLCA-549.

Keywords: cytotoxicity, antiproliferative, Phallusia nigra, HLCA-549.