Abstract
ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF BASELLA ALBA IN ACUTE AND SUB-ACUTE MODEL

Dr. P. Jhansi Rani*, Dr. Sowmya, Dr. V. Venkat Rao and Ch. M.M. Prasada Rao

ABSTRACT

The present study is carried out to investigate the anti-inflammatory potential of Methanolic extract of Basella alba (BA). Anti-inflammatory activity was evaluated by using Egg Albumin, Turpentine Oil & Formaldehyde as phlogistic agents. The animals were treated with doses 250mg/kg and 500mg/kg of extract and Diclofenac Sodium at a dose of 10mg/kg is used as a standard drug. The BA showed a significant anti-inflammatory activity in a dose dependent manner in all the models when compared with the standard treatment. The extract (500mg/kg) exhibited maximum antiinflammatory activity i.e., 46.26%, 44.34%, 46.38% (P<0.001) like standard Diclofenac 47.03%, 46.54%, 48.55% in Egg albumin, Turpentine oil and Formaldehyde induced methods respectively. Based on the above results, we conclude that the BA has significant anti-inflammatory activity and might prove efficacious for further design and development of agents with significant biological activity.

Keywords: Basella alba, anti-inflammatory activity, phlogistic agents.


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