European Journal of Biomedical and Pharmaceutical Sciences

HAEMATOLOGICAL INDICES, SERUM PROTEINS, GLUCOSE LEVELS AND HISTOLOGY OF HEART IN ALBINO WISTAR RATS CO-ADMINISTERED WITH CHLOROQUINE AND CEFUROXIME

*Oboso Edem Etim, Efosa Godwin Ewere, Monday Isaiah Akpanabiatu and Enomfon Jonah Akpan

ABSTRACT

The effects of co-administration of chloroquine (CQ) and cefuroxime (CE) on albino Wistar rats were investigated. The study included assays of haematological indices, total protein, globulin, albumin and glucose level. Histology of the heart was also investigated. Results obtained revealed that significant (P<0.05) decrease occurred in total protein and albumin in groups treated with CQ alone and total protein and globulin in groups treated with CE alone when compared with control. Also significant (P<0.05) increase occurred in total protein and globulin in group treated with both CE and CQ when compared with control. Significant increases occurred in globulin in group treated with CQ alone when compared to control. Glucose level decreased significantly (P<0.05) in all the treated groups compared to the control. There were significant (P<0.05) increases in red blood cells (RBC), haematocrit (HCT) and significant (P<0.05) decreases in mean corpuscular haemoglobin (MCH) in all the treated groups compared to control. Photomicrographs of the heart indicated stretched cardiac muscular walls with prominent nuclei following co-administration of CQ and CE. Proper caution must be taken in drug administration either as a single medication or in combination with other medications.

Keywords: Cefuroxime, Chloroquine, Haematology, Histology, Serum Proteins.