European Journal of Biomedical and Pharmaceutical Sciences

THE CONCEALING OF ?-LACTAM ANTIBIOTICS AND PROGRESS OF DETECT METHODS

Zhenping SHI and Wancui XIE*

ABSTRACT

The residue of β-lactam antibiotics has become an urgent issue of quality and safety of milk. β-lactamase conceal the existence of β-lactam antibiotics because it could decrease β-lactam antibiotics and change the antibiotics structure. As the development of antibiotic residues detection methods in milk, there is an increasing trend of adding β-lactamase into milk to decompose antibiotics. After the detection of β-lactamase become compulsory inspection items, the illegals began to consider how to conceal the existence of β-lactamase. Sulbactam could irreversibly bind with β-lactamase which could then decline free β-lactamase level even to zero. Therefore, after antibiotics and β-lactamase became mandatory testing items in milk, a phenomenon of adding sulbactam into β-lactamase-illegally-added milk to mask excessive antibiotics start to evolve. According to these situations, reviews were made on the concealing ofβ-lactam antibiotics and the corresponding detect method progress.

Keywords: milk, ?-lactam antibiotics, concealing, ?-lactamase, sulbactam.