THE FREQUENCY OF ABO BLOOD GROUPING AND RHESUS ANTIGENS AMONG SUDANESE BLOOD DONORS
Khalda Abdel Mutaa Abdel Rahman, Abdel Rahim Mahmoud Muddathir* and Ream Elzain Abdelgadir
ABSTRACT
Back Ground: ABO and Rhesus (Rh) blood group antigens are hereditary characters and are useful in population genetic studies, resolving medico-legal issues and more importantly in pre-transfusion testing in blood banking practice. Relatively little information is available regarding the frequency of the ABO and various Rhesus antigens among Sudanese population. The study was aimed to determine the frequency of those antigens among the Sudanese blood donors. Material and Methods The Study was descriptive cross sectional study, performed during May and July 2013. A total of 385 male blood donors attending Al-amal Hospital from different Sudanese ethnic groups was included in this study. The blood samples collected into EDTA containers and tested for the ABO and Rhesus typing by classical slide and tube agglutination method using commercially available anti-sera and gel micro typing system. Data were analyzed using SPSS software computer program version 21. Result: Blood group (O) was the most predominant blood group (47%), followed by blood group A (30.9%), B (17.9%) and AB (4.2%). Majority of the subjects were Rh (D) positive (93.5%) and only (6.5%) were Rh negative. The predominant Rh antigen after Rh D was Rh e- ( 93.2%) followed by c- (81.6% ) , C (38.4% ) and E (16.9%). the most common phenotype in Rh D positive samples was ccDee(42.1%) and in RhD negative it was ccdee (5.2%) .Seven samples were negative for antithetical antigens E and e while five samples negative for C and c antigens. The most probable genotype was cDe/cDe (42.1%). Conclusion concluded that the frequency of the Rh antigens can be shown in this order D > e- > c- > C > E. Special precautions need to be undertaken to minimize any possible allo-immunization by such antigens.
Keywords: ABO and Rhesus (Rh) blood group possible allo-immunization by such antigens.
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