European Journal of Biomedical and Pharmaceutical Sciences

HAEMATOLOGICAL PARAMETERS AND SOME COAGULATION PROFILE IN MALARIA PATIENTS

Enas Ali* and Dr. Enaam Abdelrahman

ABSTRACT

Background: Malaria parasites belong to the genus plasmodium. There are approximately 156 named species of plasmodium which infect various species of vertibrate. Four are known to infect humans – p.falciparum, p.vivax, p. malariae and p.ovale. It transmitted by the bite of infected anopheles mosqutoes. Malaria can cause thrombocytopenia, leucopenia, leucocytosis, anaemia and intravascular coagulation or bleeding. Objective: the purpose of this study was to assess the CBC parameters and some coagulation profile in malaria and correlate parameters with parasite density , type of malaria parasite , age and gender of patient. Materials and Method: A case control study was done in 60 malaria patient (30 plasmodium falciparum and 30 plasmodium vivax ) and 30 normal control. Complete blood count was stimated by full automated mindary and the coagulation profile was tested by coagulometer. Result: CBC count and some coagulation profile was estimated by automation showed that HB, PLTS and HCT was significant decrease and affected by increasing of density ,RBCS and WBCs and MCHC was significant decrease but they are not affected by density MCHC was affected by type of malaria. Lymphocyte and granulocyte were significant difference between p.falciparum and plasmodium vivax (p.value <0.05). PT was significant prolongation in malaria and it was affected by increase of parasitaemia (prolong), but the PTT level was shorting and also affected by incrase of parasite density. Conclusion: The study concluded that different species of malaria (falciparum and vivax ) has profound hematological effect in sudanese patients, it can cause thrompocytopenia ,anaemia ,leukopenia, prolong PT and shorting APTT.

Keywords: Malaria, falciparum, vivax, CBC, PT, PTT, Mindary, Coagulometer, parasite density.