European Journal of Biomedical and Pharmaceutical Sciences

OXIDATIVE STRESS: A POSSIBLE MECHANISM BEHIND NANOPARTICLE TOXICITY

Animesh Patra* and Sudipta Jana

ABSTRACT

Nanoparticle is nanometer sized materials or device or system. Nanoparticle were used for developmental new biomaterials and analytical tool kits .As well as for understanding life science because of their size dependent physical and chemical properties. Some of elastration for nanoparticle mediated toxicity and include oxidative stress inflammation genetic damage and the inhibition of cell division and cell death. Most work to death has suggested that reactive oxygen species (ROS) generation (which can be either protective or harmful) during biological interaction) and consequent oxidative stress are observed with nanoparticle toxicity. Few nanoparticles have been shown to active inflammatory cells such as macrophages neutrophils which can result in the increase production of ROS. And some nanoparticle likes gold nanoparticles have been investigated for bio-medical application targeting cancer.

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