European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF BORAGO OFFICINALIS FLOWERS BY PYLORUS LIGATION IN RATS

Syeda Nishat Fathima*, G. Hemalatha, K. Shailusha and Syeda Hafsa Mahjabeen

ABSTRACT

Context: Ulcer an inflamed erosions in the mucus membrane lining the alimentary tract, present in around 10% of the population due to an imbalance between the aggressive (acid, pepsin and Helicobacter pylori) and the defensive (gastric mucus and bicarbonate secretion, prostaglandins, innate resistance of the mucosal cells) factors. In recent years, abundant work has been carried out on herbal medicine to elucidate their potential effectiveness in gastric ulcer prevention or management. Objective: To evaluate the anti-ulcer activity of ethanolic extract of Borago officinalis flowers by pylorus ligation induced ulcer. Methodology: Ethanolic extract of Borago officinalis flowers were subjected to the acute oral toxicity study as per ICH Topic S7A guidelines and OECD 423 guidelines and 250 mg/kg body weight of dose was selected for further study. In pylorus ligation induced ulcer model Ulcer index, ulcer preventive index, volume and pH of gastric fluid, free acidity and total acidity were evaluated. Result: The extract showed significant reduction in ulcer index, gastric volume, total acidity, free acidity and increase in pH of gastric juice and percentage protection as compared to control. This present study indicates that Ethanolic extract of Borago officinalis flowers have potential antiulcerogenic property. Conclusions:In conclusion the antiulcer properties of the extract may be accredited to the presence of phytochemicals like polyphenols, flavonoids and substances such as gamma-linolenic acid.

Keywords: Borago officinalis, Pylorus ligation, ulcer index.