European Journal of Biomedical and Pharmaceutical Sciences

A STUDY OF RANDOM URINE PROTEIN TO CREATININE RATIO IN THE DIAGNOSIS OF NEPHROTIC SYNDROME IN CHILDREN.

*Dr. Sudhir Mehta MBBS, DCH, DNB (PEDIATRICS)

ABSTRACT

Background: The objective of the study was to evaluate the accuracy of urine protein creatinine ratio (UP/UC) in a random sample for quantitative measurement of proteinuria in comparison with 24 hours urinary protein excretion in children of nephrotic syndrome. Methods: 20 patients of nephrotic syndrome were enrolled in study and were advised regarding 24 hours urine collection. They were asked to collect 24 hours urine sample for total protein excretion rate. A random urine sample was obtained and urine protein/creatinine ratio was calculated. The data was analyzed by linear regression and by calculating the correlation coefficient between urinary protein/creatinine ratio and 24 hour urinary protein. Results: Urine total protein in a timed 24 hour sample of nephrotic syndrome patients was in the range of 40.26-126.56 mg/m2/hour with the mean value of 69.68 mg/m2/hour. While as UP/UC ratio ranged from 2.32-5.6 with the mean value of 3.38. A significant correlation (r = 0.776) was found between timed 24 hour urinary protein and UP/UC ratio. Conclusions: Thus we conclude that random urine protein-creatinine ratio is highly reliable and rapid test for quantification of proteinuria in children. It reflects the amount of protein in a 24 hour collection. Thus it avoids all the drawbacks which are associated with time collection method

Keywords: UP/UC ratio, 24 hour urinary protein, Nephrotic syndrome.