European Journal of Biomedical and Pharmaceutical Sciences

DESCRIPTIVE REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM

Mobarak Hussain*, Dr. Biswajit Das and Dr. Suvakanta Dash

ABSTRACT

Colon specific drug delivery system has attracted considerable attention for the past few years in order to develop drug delivery systems that are able to release drugs specifically in the colon in a predictable and reproducible manner. The colon is a site where both local and systemic delivery of drugs can take place. Colon targeted drug delivery system involves the targeting of drug to colon and is used for the treatment of various diseases related to colon like inflammatory bowel disease, colon cancer, crohn’s diseases etc. Beside these different new approaches were also used for colon targeting like pressure controlled, osmotic controlled drug delivery systems are highly effective. This review is aimed at understanding recent approaches for dosage forms which is targeting to colon through pH sensitive system, microbial triggered system.

Keywords: Crohn’s diseases, pH sensitive, colon cancer, osmotically controlled system.