European Journal of Biomedical and Pharmaceutical Sciences

PRIMARY DIFFUSE LARGE B CELL LYMPHOMA OF PROSTATE: A RARE CASE REPORT

Dr. Sasmita Panda, *Dr. Asaranti Kar, Dr. Upasana Das, Dr Sagarika Samantray, Dr. Niranjan Rout, Dr. Bidyut Prava Satpathy and Dr. Pragnya Paramita Nayak

ABSTRACT

Primary lymphoma of the prostate is a rarely encountered entity in surgical pathology. Usually it presents as secondary involvement from leukemia or lymphoma at a common site. Out of these, chronic lymphatic leukemia or small lymphocytic lymphoma is commonly detected. Prostatic non-Hodgkin lymphoma is extremely uncommon accounting for approximately 0.2-0.8% of extranodal lymphomas and 0.1% of all prostate neoplasms. Here we report the case history of a 48 year old man presenting with urinary obstructive symptoms and normal prostate specific antigen value. After open prostatectomy, histopathological examination revealed diffuse infiltration of atypical lymphoid cells in the stroma and atrophy of the prostatic glands. Positive immunostaining for CD 45 and CD 20 positivity and negative staing with CK proved the case as diffuse large B cell lymphoma. The patient did not have hepatomegally or spleenomegally. After receiving RCHOP regimen the patient is doing well for last 14 months.

Keywords: CD20, CD45, CK, diffuse large B cell lymphoma, prostate.