Abstract
EFFECT OF METHANOL EXTRACT OF OCIMUM GRATISSIMUM LEAVES ON LIPID PEROXIDATION AND LIPID PROFILE STATUS IN CCL4-INDUCED HEPATOTOXICITY IN ALBINO RATS

*Aanuoluwa James Salemcity, Victoria Obiageli Nwaneri-Chidozie, Olakunle Oladimeji, Emmanuel Ekpa, Blessing Titilope Olugbemi, and Esther Ojomenewu Ukwedeh

ABSTRACT

Effect of methanol extract of Ocimum gratissimum leaves on lipid peroxidation and lipid profile status in CCl4-induced hepatotoxicity in albino rats was investigated for a period of two weeks. Thirty rats were divided into six groups: Group A (Normal rats), Group B (CCl4- induced rat) and Group C, D, E and F (CCl4 + various doses of the extract). There was no significant difference (P<0.05) in the lipid profile of the rats treated with the extract relative to the control group A. Also, ameliorative effect of the extract was observed as it lowered the lipid peroxides generated by CCl4 in the treated groups when compared with the control group A. Consequently, the above results suggest that methanol extract of Ocimum gratissimum leaves could serve as a good antioxidant and hypolipidermic agent.

Keywords: Ocimum gratissimum leaves, carbon tetrachloride, methanol extract, hepatotoxicity, lipid peroxidation.


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