Abstract
PRONIOSOMES FOR ORAL DELIVER OF MELOXICAM: FORMULATION AND IN VITRO EVALUATION

Nagarathna G., Parthiban S.*, Senthil Kumar G. P. and Tamizh Mani T.

ABSTRACT

Meloxicam loaded sorbitol and mannitol based proniosome were prepared by slurry method with different surfactant ratio. The proniosome formulation was evaluated for FT-IR study and scanning electron microscopy. The niosomal dispersion was further evaluated for entrapment efficiency, in-vitro release study, kinetic data analysis, stability study. The result from SEM analysis has showed smooth surface of proniosome. The formulation FS3 and FM3 which showed entrapment efficiency 77.18% and 73.24% respectively. In vitro cumulative drug release 59% and 62% respectively at the end of 12 hrs. Release kinetic was found to be best among the all 6 formulations. Release was best explained by the higuchi model. Kinetic analysis showed that the drug release follows non-fickian release.

Keywords: Meloxicam, Proniosome, sorbitol and mannitol.


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