Abstract
RECONSTRUCTION OF BONE DEFECT WITH THE CORAL SCAFFOLD AND OSTEOBLASTS: AN EXPERIMENTAL STUDY IN RABBITS

Thao Duy Huynh, Ciro Gargiulo, Vu Quoc Vo, Hoa Khanh Nguyen, Toai Cong Tran*

ABSTRACT

Demand for bone grafts to treat bone defects in cases of pathologically and injuries is increasing, but the source of bone graft derived from humans is not enough to supply the needs of patients. Therefore, research and create the equivalent of bone graft is a necessary work but also a long-term solution in the future. The present study was carried out with the goal of creating the equivalent bone graft using sea coral (Porites lutea species) as the substrate to contain osteoblasts derived from bone marrow to treat defects bones in the body of the rabbit femur bones. This is a controlled experimental study. Rabbits were divided into two groups, Group 1 (experimental rabbits), including the rabbit pieces were grafted by the coral contained osteoblasts. Group 2 (control group) consisting of rabbits were grafted by coral alone. Research results on the rabbits were evaluated at the time points of 1, 3 and 6 months by radiology and histology (H & E staining). From this study, we found that the group of rabbits that were grafted by coral containing autologous osteoblasts, the bone healing results occur faster and better quality of bone healing when compared with the control group at time study 1 month and 3 months. The study results will open up the prospects of clinical applications in the future for bone defects cases, this will be a long term solution and effective for patients when there is not enough bone graft source, in while autologous bone grafting is limited in terms of quantity.

Keywords: sea coral, osteoblast, bone defect, grafting, reconstruction.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2023 Issue has been successfully launched on 1 FEBRUARY 2023.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT