Abstract
A WORK ON SYNTHESIS AND CHARACTERIZATION OF NOVEL PURINE AMINO ACID DERIVATIVES WITH ANTIMICROBIAL EVALUATION.

Paresh Shende* and K. Vyas

ABSTRACT

A series of novel Purine coupled with different amino acids derivatives were synthesized, characterized and their antimicrobial properties were evaluated. These compounds were synthesized with 2-ACP react with n-propyl bromide coupling with various amino acids to get Purine propyl amino acids. The synthesized Purine propyl amino acids act as cobalt chloride to get intermediate compound of [(2-chloro-9-propyl-9H-purin-6-yl) amino] acetic acid. Finally intermediate compound condensed with morpholin, piperidine, methyl piperidine, Piperazin to get desired compound. Final compound characterized using IR, 1H and 13C-NMR The synthesized compounds were screened for their in vitro antimicrobial activity against S. aurous, E. coli, P. aeruginosa, S. typhimurium, F. oxysporum and A. alternate. Some of these compounds exhibited moderate to good activity, where as some were inactive.

Keywords: 2- ACP, Amino acids, antimicrobial activity, coupling, Intermediate.


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