Abstract
THE ROLE OF OBESITY IN ALTERATION OF PROSTAT SPECIFIC ANTIGEN AND ACID PHOSPHATASE IN ADULT YOUNG SUDANESE MALES

Hala Alameen Abbas* and Nasr aldeen Mohammad

ABSTRACT

Background: serum prostat specific antigen(pSA) and acid phosphatase(ACP)adiagnostic biomarker of prostate problem and is possibly associated with obesity. The purpose of this study to detect the role of obesity in alteration of (PSA) and(ACP) In adult young obese male and other with normal weight as control with different body mass indx. Methodology: Acase control study involving 40adult young sudanese obese males(BMI>30kg\m), the mean age between 18-40years, control group was included 40 healthy volunteer males with normal weight(BMI20-25kg\m) were analyze of ACP by spectrophotometr and PSA by using ELISA. Result: showed signficant decrease in PSA In study group comparint to the control group,that is due to heamodilution and metabolic syndrome. negative correlation between age and ACP (p value0.00) and insignificant change in PSA(P value 0.07). highly negative **Correlation(t 0 .0) PSA and ACP with increase of BMI. Conclusion: The level of prostate specific antigen and acid phosphatase decrease with obesity that may casuse mask to aerly detecation of prostate cancer.

Keywords: prostate specific antigen, body mass index, Acid phosphatase,obesity, prostate cancer.


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