DIPYRIDAMOLE ATTENUATES THE GASTRIC INJURY IN ADULT AND AGED FEMALE RATS
S. Hassan*, A. Rashad and G. H. Heeba
ABSTRACT
Age is one of the important factors that affect the drug effects. Gastric ulcer is a common disease especially in elderly. Patients, especially elderly, who are treated with anti-platelet drugs may be exposed to a risk of gastric ulcers. Dipyridamole (DPY) is a platelet inhibitor that is primarily recognized as an antithrombotic agent. The aim of this study is to evaluate the age-dependent effects of DPY against cold restraint stress (CRS)-induced gastric ulcer in adult and aged rats. In addition, the possible mechanisms occupied in the effects were evaluated. DPY was suspended in 2% arabic gum solution and orally administered at a dose of 10 mg/kg once daily for 2 weeks and the last dose was administered 30 min before CRS. DPY exhibited gastroprotective effects in both adult and aged rats as evidenced by significant decreases in ulcer index (U.I). Both adult and aged DPY treated groups showed significant decrease in gastric mucosal malondialdehyde (MDA) concentration and myleoperoxidase (MPO) activity with concomitant increase in gastric mucosal content of reduced glutathione (GSH), nitric oxide (NO), prostaglandin E2 (PGE2) levels and gastric juice mucin concentration compared to CRS-induced gastric ulceration in adult and aged rats, respectively. This protective effect of DPY was confirmed by gastric histopathological examination. In conclusion, DPY protected both adult and aged rats’ gastric mucosa against CRS-induced gastric ulceration possibly through enhancement of gastric mucosal defense, anti-oxidant and anti-inflammatory activities. Accordingly it is concluded that DPY represents a suitable antiplatelet agent for patients who are at risk of gastric ulcers especially elderly patients.
Keywords: Dipyridamole- Gastric ulcer -Aged rats- Antioxidant - Anti-inflammatory.
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