EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF TECTONA GRANDIS SEEDS BY USING CCL4-INDUCED HEPATIC INJURY IN RATS.
Jangme C. M.*, Shivakumar S. Ladde and Wadulkar R. D.
ABSTRACT
Liver failure can result from any type of liver disorder, including viral hepatitis (most commonly hepatitis B), cirrhosis, and liver damage from alcohol or drugs such as acetaminophen. Herbal drugs play a significant role in the regeneration of liver cells and acceleration of healing process and hence management of many liver disorders. Based on the fact that a tremendous number of plants could be considered as a gold mine for discovery of hepatoprotective agents, we launched our study in a trial to investigate the hepatoprotective activity of Tectona grandis seeds by using CCl4-induced hepatic injury in rats. In the preliminary phytochemical studies confirmed the presence of carbohydrates, Phenolic compounds like tannins, flavonoids, and saponins.CCl4 treated group showed significant increase in the levels of AST, ALT and ALP as compared to that of vehicle treated normal control rats. The PTG 400 mg/kg, and Silymarin 50 mg/kg showed significant and equipotent (P<0.01) reduction in elevated levels of these enzymes and showed hepatoprotective effect. PTG 200 mg/kg was effective to reduce AST levels only whereas PTG 100 mg/kg was not significant at all. The result of the present study clearly indicates that the petroleum extract of Tectona Grandis Linn seed possesses potent hepatoprotective activity against CCl4 induced hepatotoxicity, which claims its traditional use as a hepatoprotective agent.
Keywords: Hepatotoxicity, Tectona grandis, CCl4, AST, ALT and ALP.
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