European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF ABDOMINAL OBESITY ON BONE MINERAL DENSITY IN PRE AND POST MENOPAUSAL DIABETIC WOMEN

Kavita Bakshi* Sabiha Vali and Dr. Sunil Gupta

ABSTRACT

Diabetes and menopause pose a twin challenge. Women may gain weight during the transition stage of menopause which may poses a risk for osteoporosis. The investigation aimed to assess the effect of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist hip ratio (WHR), waist height ratio (WHtR) and Glycosylated hemoglobin (HbA1C) on Bone Mineral Density (BMD) in diabetic pre and postmenopausal women. Type 2 diabetic women, 100 premenopausal, 111 postmenopausal were selected by purposive sampling from Diabetes Care n Research Center, Nagpur. Anthropometric measurements, HBA1c and BMD were assessed by standard methods.. Mean age was 46+5.64 and 60 +6.30 respectively in pre and postmenopausal women. Significantly higher (p=0.0001) BMI of pre menopausal subjects (28.69 +5.261) than post menopausal subjects (28.02 +4.599) was observed. WHR was higher than the WHO criteria (<0.85) in more than 80% of the subjects. High percentage of both pre (94%) and postmenopausal subjects (95.5%) had a WHtR above 0.6. Insignificant difference (p=0.1230) in HbA1c between the two group of subjects (8.71 +2.10 & 8.40 +1.69 in pre and post menopausal subjects respectively) was observed. Low mean BMD T scores of pre (-1.43+0.94) and post menopausal subjects (-1.80 +-0.94) was suggestive of osteopenia. A higher value of WHR and WHtR is correlated with abdominal obesity. Pre menopausal diabetic subjects with abdominal obesity are therefore prone to changes in bone density and need to be cautioned to prevent entering menopausal stage with osteopenia a precursor to osteoporosis.

Keywords: BMD, HbA1c, WHR, WHtR.