EVALUATION OF PLASMA BETA2-MICROGLOBULIN FOR EARLY DETECTION OF CHRONIC KIDNEY DISEASE IN SUDANESE PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES MELLITUS - KHARTOUM STATE
Reem Abdelmohssin Ali*, Ayman Ali Mohammed Alameen and Tarig Mohamed Fadl Elmula
ABSTRACT
Background: Beta2-microglobulin is a marker used for early detection of chronic kidney Disease in high-risk patients (hypertension and type 2 diabetes mellitus). Methodology: case-control study in which 75 subjects were enrolled with age ranged 40-80 yrs and different gender. Patients were classified into two groups, diabetics and hypertensive (with different duration), and the rest of participants as control. Renal Function Test (serum creatinine and blood urea) and beta2-microglobulin were measured. Results: seventy five individuals included in this study, of whom 50 diabetic and hypertensive patients: diabetic male 5 (20%) and 19(80%) were female, 8 (32%) hypertensive male and 17 (68%) female. 25 apparently healthy subjects 14 (56%) male and 11 (44%)female. Glucose level and beta2-microglobuline was significantly increased in diabetics and hypertensive Patients when compared to the control group (P-value = 0.001, 0.000 respectively). There a positive correlation between duration of type2 diabetes and hypertension and levels of beta2-microglobulin. Conclusion: Beta2-microglobuline was significantly increased in high-risk population and correlated with duration of type2 diabetes and hypertension. It might a good marker for early detection of chronic kidney disease in such patients.
Keywords: Beta2-microglobulin (B2MG).chronic kidney disease.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
