Abstract
HISTOMORPHOLOGICAL AND BIOCHEMICAL ASSESSMENT OF TESTICULAR PARAMETERS FOLLOWING ORAL ADMINISTRATION OF CADMIUM NITRATE TO ADULT MALE WISTAR RATS

Sunday Aderemi Adelakun*, Grace Temitope Akingbade, Julius Akomaye Aniah, Olajide Olasunkanmi Modupeoluwa

ABSTRACT

Background: Available evidence shows that cadmium nitrate (CdN) is locally used in Africa as a supplement in the preparation of herbal mixture. This study focused on histomorphological and biochemical assessment of testicular parameters following oral administration of CdN in adult male wistar rats. Materials and Methods: Twenty (n=20) adult male wistar rats were randomly divided into four groups (A-D) of five (n=5) rats each. Group A served as control was given 10 ml/kg/day of distilled water. Group B, C, and D [cadmium nitrate (CdN) group] were given 100 mg/kg/bw of CdN, 200 mg/kg/bw of CdN and 300 mg/kg/bw of CdN respectively. Administration was done by gastric gavage once a day, for fifty-six consecutive days. Testicular weight and semen analysis revealing the sperm count, sperm motility, and sperm morphology were assessed. Malondialdehyde (MDA),Superoxide dismutase(SOD) GSH(Glutathtone reductase) were also examined. The Testis of each rat were harvested and fixed in Bouin’s fluid for histological analysis. Results: Histological result revealed depletions in spermatogenic cells in germinal epithelium. The body weights of the experimental group significantly increased throughout the period of the experiment when compared with the control. Testicular weights and sperm quality of the experimental group were significantly decreased in a dose dependent manner. There is significant increase in the activity levels of MDA, SOD, and GSH in the experimental groups when compared with the Control. Conclusion: This study showed that CdN induced alteration in testicular weight, semen parameters and oxidative stress parameters in the testis of adult male wistar rat.

Keywords: Cadmium Nitrate; testes; spermatogenic; cells; sperm.


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