European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF THE NUMBER OF MAST CELLS IN PERIAPICAL CYST AND PERIAPICAL GRANULOMA

Molook Torabi Parizi, Hossein Karimi Afshar, Maryam Rad* and Ramin Afshar Manesh

ABSTRACT

Mast cells are large granular cells that arise from a multipotent precursor in the bone marrow and play an important role in regulation of vascular permeability. The present study was, undertaken to identify as well as quantify mast cells in periapical cyst and periapical granuloma and compare it with the average count of mast cells in normal oral mucosa. Ten cases of normal oral mucosa and thirty four cases of periapical cysts and 29 cases of periapical granuloma for mast cell number using 1% toluidine blue. Data analyzed in SPSS soft ware using ANOVA and Tukey’s test. P value at 0.05% was considered as significant level. A statistically significant increase was in the mean of average mast cell count per high power field in radicular cyst and periapical granuloma in comparison to normal oral mucosa. There was no statistically significant increase in the mean of average mast cell count in radicular cyst and periapical granuloma. The results of the present study show mast cells may play a role in radicular cysts.

Keywords: Mast cell; Periapical granuloma; Radicular cyst.