ANTIMICROBIAL ACTIVITY OF SUDANESE HONEY AGAINEST STAPHYLOCOCCUS AUREUS WOUND ISOLATES COMPARED WITH MANUKA HONEY
Asmaa M. A. Khaierelseed, Luai O. I. Marouf, Musa A. Ali, Awad Alla H.O. Kashif*
ABSTRACT
Background: Methicillin resistant Staphylococcus aureus is a major cause of nosocomial and community acquired severe human infections worldwide. The aim of this study was to determine the antimicrobial activity of some types of Sudanese honey against methicillin-resistant and methicillin-susceptible Staphylococcus aureus from wound isolates in contrast with Manuka honey. Methods: A total of thirty wound isolates confirmed methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains were selected based on cultural characteristics, reactions in standard biochemical tests and routinely used antibiotics. The antimicrobial effect of different concentrations (v/v) of Sont (Acacia nilotica) and Sidr (Ziziphus spina-christi) Sudanese honey and Manuka honey (Leptoapermum scoparium) UMF® 10+ were tested using agar incorporation method in Muller-Hinton (MH) medium at 56 °C to detect the minimum inhibitory concentration (MIC). Results: The minimum inhibitory concentration of Manuka honey was detected at concentration 10% for both methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains. Higher minimum inhibitory concentrations, 30% and 50% were detected for Sont honey and Sidr honey respectively. Conclusions: Whilst Manuka honey showed better results than Sudanese honeys tested in this study nevertheless, these honeys possess reasonable antimicrobial activity against both methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolated from wound.
Keywords: Staphylococcus aureus, Methicillin-resistant, Sudanese honey, Manuka honey.
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