European Journal of Biomedical and Pharmaceutical Sciences

RECENT ADVANCES OF SMART POLYMERS FOR SUSTAIN RELEASE DRUG DELIVERY

Bibhuti Sonowal*, Pranjal Ray, Dr. Pulak Deb and Dr. Suvakanta Dash

ABSTRACT

Polymers are the core ingredient in the formulation and development of drug product. They have certain characteristics in designing and modification of the formulation in drug delivery system. This delivery system may require polymers in the form of carrier, colloidal or as nanoparticles which show great advantages in drug loading as well as in releasing of active drug moiety. Smart polymers are slightly different from such polymers because smart polymers have the ability to transform its microstructure or physical structure with the change in temperature, pH, biological enzyme, radioactive agents etc. Natural as well as synthetic polymers have been used in making the production and formulation system a very simple and low cost. Through these polymers the designing and formulation system of controlled drug delivery have became quite easy for the researcher. Targeted release and sustain release of drug can be obtained by overcoming the difficulties like poor bioavailability and short half life drug.

Keywords: smart polymer, stimuli responsive, control release, targeted delivery.