European Journal of Biomedical and Pharmaceutical Sciences

DESIGN AND SYNTHESIS OF NOVEL BENZIMIDAZOLE THIOSEMICARBAZIDE AS POTENT ANALGESIC AND ANTI-INFLAMMATORY AGENTS

Pullagura M. Krishna Prasad and Raja S.*

ABSTRACT

With the aim of developing potent analgesic, and anti-inflammatory agents a series of novel benzimidazole semicarbazide derivatives were synthesized and characterized by FT-IR, 1H-NMR, Mass spectroscopy and bases of elemental analysis. Tail-flick technique, and carrageenan-induced foot paw edema test were performed for screening analgesic, and anti-inflammatory, respectively. Moreover all potent compounds were examined for its ulcerogenicity. Results revealed that entire series of compounds exhibited mild to good analgesic, and anti-inflammatory activity. The potent analgesic and anti-inflammatory active compounds displayed low to moderate ulcer index. From the study it was found that, in this series nature of the substituent played a major role in analgesic and anti-inflammatory activity than its position. Compound 1-(4-chlorobenzylidene)-4-(4-(1-((dimethyl amino)methyl)-1H-benzimidazol-2-yl)phenyl)thiosemicarbazide VIc was determined to be the most active compound.

Keywords: Benzimidazole, Thiosemicarbazide, Analgesic, Anti-inflammatory, Ulcerogenicity.