Abstract
ANTICONVULSANT ACTIVITY OF FLOWER EXTRACT OF COSTUS SPECIOSUS (COASTACEAE) IN EXPERIMENTAL ANIMALS

Kanakam Vijayabhaskar*, Mathukumalli Sai Laxmi, Bairi Padma, Kyatham Hemanth, Nimma VijayaRekha, Kalakota ChaitanyaPrasad

ABSTRACT

Objective: The main objective of the work was to evaluate the anticonvulsant activity of Costus speciosus Methods: The anticonvulsant activity of methanolic and aqueous extract of Costus speciosus flowers was evaluated using Pentylenetetrazole (PTZ) induced convulsions in mice and maximal electro shock (MES) induced Convulsions and lithium-pilocarpine induced status epilepticus in rats. Results: methanolic and aquoeus extract of Costus speciosus (100 and 200 mg/kg) and (200 mg/kg) delayed onset of PTZ- induced convulsions and also prolonged the onset of tonic convulsions in mice. Both the extracts failed to protect the rats from MES induced convulsions. The extracts also protected rats against seizures induced by lithium-pilocarpine. In Lithiumpilocarpine model the methanolic extract (100 and 200 mg/kg) and aqueous extract (200 mg/kg) delayed the latency to rearing with forelimb clonus significantly. Conclusion: The results indicate that which are active in case of Pentylenetetrazole (PTZ) and lithium pilocarpine induced status epilepticus, which support the ethnomedicinal application of the plant as an anticonvulsant agent.

Keywords: Costus speciosus, Anticonvulsant, Pentylenetetrazole, Maximal electroshock, Lithium-pilocarpine,


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