European Journal of Biomedical and Pharmaceutical Sciences

IN VITRO EVALUATION ANTIMICROBIAL ACTIVITIES OF CINNAMOMUM ZEYLANICUM AND COMPARED WITH SOME ANTIBIOTICS

Alaa M. Nassar*, Ahmed A. Nasar Alamiry and Sukaina R. Neamah

ABSTRACT

The Antimicrobial properties of the ethanolic extract of Cinnamomum zeylanicum bark were assayed for the in vitro antimicrobial activity against gram-positive standard bacteria represented by Staphylococus aureus and Staphylococcus epidermides and gram-negative standard bacteria represented by Escherichia coli and Pseudomonas aeruginosa using holeplate diffusion method. All the extracts studied in the present investigation exhibited varying degree of inhibitory effect against all the tested human pathogenic bacteria .The results shows the higher inhibition zone of all extracts for gram positive which ranged between 20.94 mm to 18.83 mm compare with gram negative bacteria which ranged between 17.55 mm to 14.38 mm. Also It can be seen antibacterial activity of Cinnamomum zeylanicum is 33.22 mm. Compare with The screening results of the Sensitivity test which revealed that the E.coli was highly sensitive to Amikacin and Oxytetracycline were (24 and 20 mm respectively). The results also revealed that Amoxicillin/clavulanic acid had moderate effect as 13 mm (Zone of inhibition) while Cefdinir had lowest effect as 8 mm. On the other hand E.coli was resistant against Ceftazidime, Carbeniciln and Cefuroxime. The zone of inhibition was recorded highly sensitive to Amikacin and Oxytetracycline were (28 and 20 mm respectively) against P. aeruginosa.while Amoxicillin/ clavulanic acid, Cefdinir, Ceftazidime, Carbeniciln and Cefuroxime had no effect of its. The zone of inhibition of antibiotics was measured against S. aureus were Erythromycin and Norfloxacin recorded the maximum zone of inhibition was (16 and 15 mm) respectively, while low susceptibility was measured by Lincomycin (9mm), On the other hand Sulfisoxazole and Ampicilin had no effect on S. aureus. S. epidermidis was highly sensitive to Norfloxacin where the zone of inhibition recorded as 38mm, while. Sulfisoxazole showed lowest effect on the growth of S. epidermidis as 8 mm. On the other hand Erythromycin, Ampicillin, and Lincomycin had no effect on it. Compare with The screening results of the medicinal plants extracts in the present study confirmed a source of antimicrobial agents by the highest sensitivity was recorded of its.

Keywords: Cinnamomum zeylanicum, Staphylococus aureus, Staphylococcus epidermides.