EFFECT OF VARIOUS FRACTIONS OF CAMEL MILK ON DIABETIC AND SUPEROXIDE DISMUTASE PROFILE
*Sarwar M, Mazin O. Mohager and A.Z. El-Bahrawy
ABSTRACT
Diabetes is steeply turning into epidemic especially in third world countries. Efforts are being pooled to counter this present day menace. In this connection, existing diabetic treatment is expensive and at time with lots of side effects. Along with new regime of medicines, scientists are looking for complementary medicines. Camel milk has
been shown in literature for its anti diabetic potential and a promising candidate as a complementary tool for the prevention and treatment of diabetes. In present study, camel milk was extracted with Alcohol, Chloroform and Ether at low temperature. Standard methods of extraction at low temperature have been adopted. Streptozotocin induced diabetes was produced in experimental mice with three consecutive intraperitoneal injections. Along with solvent fractions, left over residues have been collected and analyzed for anti diabetic activities. It was revealed that Residues of Extracted Camel Milk (RECM) have maximum hypoglycemic and reduction of Hb1ac activity. Alcohol ranked second in this line. Chloroform and Ether fractions also have anti diabetic activity but at lesser extent. RECM by stimulation or regeneration released more insulin in the blood of diabetic mice. RECM also raised Superoxide Dismutase in streptozotocin treated mice. Alcohol, chloroform and ether extracts also raised superoxide Dismutase. Elevation of Superoxide dismutase and suppression of glucose profile in response to various fractions of camel milk shows that it is a plausible agent to lessen the long term complications of diabetes and have potential to become modern day neutraceutical.
Keywords: Camel milk, RECM, Streptozotocin, Insulin, SOD.
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