Abstract
SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF SOME NOVEL ESTER-ETHER PHENOL DERIVATIVES

Talal H. Zeglam, Omran N. R. Fhid*, Asma.Gebril, Massud A.S.Anwair,
Reham M.Mufti and Zakia A.Ghanfoud

ABSTRACT

In the present study a new ester–ether phenol derivatives 2-5 have been synthesized and characterized. Their structures have been established on the physical and spectral analysis. The synthetic compounds were screened in vitro for their antimicrobial activity against: Metacillin resistance staphylococcus aureus, Escherichia coli ATCC 11934, Extended spectrum B-lactamase (12,54,70), staphylococcus aureus, Bacillus subtales and Candida albicans (669,1047, 772, 1057, 660). The best result obtained at the concentration 100μg with compound phenyl benzoate 2 and 1-Nitro-4(phenoxymethyl)benzene 5 against fungus (Candida albicans 660, 1047, 1057 ). While Compound 5 possess significant active against gram positive and gram negative bacteria comparable to that of the standard drugs.

Keywords: Phenol, Ester-Ether Phenol derivatives, antimicrobial activity.


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