SYNTHESIS, MOLECULAR PROPERTIES PREDICTION AND BIOLOGICAL ACTIVITY OF 2-PHENYLINDOLIZIN ACETAMIDE DERIVATIVES
Balusu Phani Kumar, V. S. R. Prasad and A. Jaya Shree*
ABSTRACT
The discovery of camptothecin and its analogs was the major breakthrough through which ‘Indolizine moiety’ came into limelight. A novel compounds, 2-Phenylindolizin acetamide derivatives (8a-8k) has beensynthesized by the reaction of 2-oxo-2-(2-phenylindolizin-3-yl)acetyl chloride(6) with different aromatic compounds (7a-7h) in presence of triethyl amine in DCM.The synthesis and screened for their Antimicrobial activities of novel class of 2-Phenylindolizin acetamide scaffolds are described by variation in therapeutic effects of parent molecule. Result revealed, the target compounds 8a, 8band8f exhibited a remarkable increase of antimicrobialactivity than CPF against in three medically relevant organismslike staphylococcus aureus, escherichia coli, pseudomonas aeruginosa is observed. Further,8d and 8ashowed better activity against antifungal starins candida albicans, aspergillus flavus and aspergillus fumigates. In present investigation, the target compounds 8a-8h were subjected to insilico molecular properties prediction and drug likeness by employing Molinspiration (Molinspiration, 2014) and Mol-Soft (MolSoft, 2007) property explorer toolkits for predicting their high oral bioavailability.
Keywords: Indolizines, Antimicrobial activity, Molinspiration, Molsoft.
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