European Journal of Biomedical and Pharmaceutical Sciences

ETHANOLIC EXTRACT OF AEGLE MARMELOS MEDIATES ITS HYPOCHOLESTEROLEMIC EFFECT BY RETARDING CIRCULATORY OXIDIZED LDL FORMATION VIA 12/15 LIPOXYGENASE PATHWAY

Singh Abhilasha, Chakrapani Lakshmi Narasimhan, Srinivasan Ashok Kumar, S. Narasimhan Kishore Kumar, Ravi Divya Bhavani, Mohan Thangarajeswari, Velusamy Prema and Periandavan Kalaiselvi*

ABSTRACT

Hypercholesterolemia is one of the prominent risk factors for the development of cardiovascular disease (CVD) and when conjugated with ageing, the progression of CVD has devastating complications. Aegle marmelos (AM) plants have been traditionally used for curing many human ailments. The present study was designed to investigate the hypocholesterolemic effect of ethanolic extract of AM in aged male Wistar rats when fed with high cholesterol diet (HCD) and prerogative modulation of ROS mediated inflammation and its signalling leading to pro-atherogenic events. The lipid profile along with lipid peroxidation and the activity of antioxidant enzymes i.e., superoxide dismutase, glutathione peroxidase and catalase were measured in all the experimental groups. We have also assessed the levels of 12/15-Lipoxygenase and C - reactive protein which act as biomarker in the development of further complications. The findings of the study reveal that the ethanolic extract of Aegle marmelos leaves can effectively control initial events of atherosclerosis by restoring the high cholesterol induced impaired redox status and further ameliorate the Reactive Oxygen Species(ROS) mediated inflammation to near normal levels suggesting it to be a potential candidate as a hypocholesterolemic agent.

Keywords: Aegle marmelos; Hypercholesterolemia; 12/15 Lipoxygenase, Cardio vascular disease (CVD).