Abstract
MONTMORILLONITE-ALGINATE COMPOSITE BEAD AS DRUG DELIVERY VEHICLE FOR THE EXTENDED RELEASE OF AN ANTIBIOTIC DRUG

Arun Kant and Monika Datta*

ABSTRACT

The present study is aimed at developing Montmorillonite (Mt) Alginate (ALG) composites bead as drug delivery vehicle for the extended release of an antibiotic drug, Metronidazole (MTZ). ALG-MTZ and Mt-ALG-MTZ composite bead were synthesised by the modification of the reported procedure.[1, 2] Interaction of MTZ with ALG and Mt was studied and presented with a proper mechanism. The synthesized ALG-MTZ composite bead and Mt-ALG-MTZ composite bead have been characterized using appropriate analytical techniques. The in-vitro release behaviour of MTZ from the synthesized ALG-MTZ and Mt-ALG-MTZ composite bead were investigated in the simulated gastric and intestinal fluids. From the in-vitro drug release data possible bioavailability of MTZ in case of for ALG-MTZ and Mt-ALG-MTZ composite bead have been calculated and it has been observed that, compared to the pure MTZ and the commercially available tablets (Metrogyl and Flagyl) performance of the synthesised ALG-MTZ and Mt-ALG-MTZ composite bead has not only been found superior in terms of probable percentage bioavailability but also in terms of availability of the drug in the system for a longer period of time.[3]

Keywords: Montmorillonite, Alginate, Encapsulation, Kinetics and extended release.


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