ORGANOCHLORINE TOXICITY ON LIVER OF SWISS ALBINO RATS
*Sabiha Khan
ABSTRACT
Endosulfan, a organochlorine insecticide, is being used extensively and its broad-spectrum activity in commercial agriculture, poultry, livestock, home and garden pest control were administered with endosulfan. In the present study, the histological changes in the liver of Endosulphan-treated rats were significantly different from that of the normal control rats. Few hepatocytes appeared swollen and empty with indistinct cell membranes. Their, nuclei were also enlarged. The nuclear membrane of a few of these cells was lost. The size of the nucleus is an indicator of functional activity of the cell. Therefore, the observed increase in the size of nucleus suggests that these cells are over actively involved in the metabolism of endosulphan. The disrupted pattern of hepatocytic cords, capsular fibrosis, subcapsular inflammatory cells, enlarged hepatocytes, evidence of increased cellular metabolism coexistent with ballooning degeneration, microvesicular and macrovesicular fatty changes, cytoplasmic basophilia, fibrosis and inflammatory infiltrate around the portal triads along with the dilatation and congestion of the blood vessels and proliferation of bile ducts and areas of hemorrhage are suggestive of toxic hepatitis.
Keywords: Hepatocytes, fibrosis, hepatitis.
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