European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF CIGARETTE SMOKING ON PLASMA LEVEL OF CALCIUM AND PHOSPHATE IN SUDANESE MALE SMOKER

Eiman Hashim Elkhalifa* and Adel Nasr Morsi

ABSTRACT

Background: Cigarette smoking has a harmful effect on the body. Numerous toxic substances are found on tobacco smoke, leading to hormonal disturbance which is responsible for regulation of plasma calcium and phosphate. The aim of my study is to evaluate the effect of cigarette smoking on plasma level of calcium and phosphate. Methodology: This case control study was carried out in Khartoum state in period from (March 2017-April 2017), total of 100 Sudanese male were involved in this study (50 smokers and 50 nonsmokers as control group). Plasma calcium and phosphate were estimated using cobas 400 -integra. Results: The result revealed s i gnificant decrease (p value =.000) in plasma c a l c i u m in smokers group compared to control (8.3 ±0 .67) (8.8± .46)mg/dl respectively and significant increase (p value=.032) in plasma phosphate compared to control (3.5 ± 0.57)( 3.2 ± 0.68) respectively, Calcium negatively correlated with number of cigarette (p value= .012, r= -0.352) and period of smoking (p value= .001, r= -0.446), while phosphate is positively correlated with number of cigarette per day (p value=.000, r=0.581)and period of smoking (p value= .045,r =,284). Conclusion: the effect of cigarette smoking on plasma level of calcium and phosphate was proved, with significant decrease of plasma calcium and increase of plasma phosphate and significant positive correlated with period of smoking and number of cigarette per day in case of phosphate, significant negative correlated with both in case of calcium.

Keywords: smoking, calcium, phosphate.