Yassen M. Yassen, Hanan H. Ahmed* and Mohamed Shawky Salem


The development of cancer is associated with several genetic and environmental factors. In addition, many studies showed an association between the development of cancer and bacterial and viral infections for decades. In this study, we aimed to collect and identify various types of bacterial species isolated from patients diagnosed with hepatic carcinoma using different isolation and identification techniques as a preliminary step towards setting of complete profile and thus an early alarm for all possible bacterial infections associated with liver diseases. 204 blood samples were collected from patients diagnosed by hepatocellular carcinoma attending medical labs from 2014to 2015. Different media types were used for isolation of pathogenic and potential pathogenic bacteria associated with hepatocellular carcinoma. Bacterial isolates were purified by sub-culturing and identified using analytical profile index (API) test kits. Specimens were also subjected to some biochemical tests including liver enzymes, glutamic pyruvic transaminase (GPT), glutamic oxalo acetic transaminase (GOT), alkaline phosphatase (ALP) activities, and albumin and Alfa-fetoprotein levels as a tumer marker. Hundreds of bacteria were isolated on different Isolation media; however, the most distinguished species were Staphylococcus aureus, Enterobacter aerogenes, Klebsiella sp and Salmonella typhi confirmed with 16sr RNA technique. Based on these results, hepatocellular carcinoma patients are more susceptible to be infected with these bacterial strains. Further studies on a larger scale are required to can set a clinical profile pointing-out the most probable bacterial strains affecting those patients and the best strategies for prevention and treatment.

Keywords: Bacteria, carcinoma, Liver, infections.

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