Abstract
MIDAZOLAM VS. BUPRENORPHINE: PATIENT CONTROLLED EPIDURAL ANALGESIA FOR POSTOPERATIVE PAIN IN GASTRECTOMY

Tomoki Nishiyama*

ABSTRACT

The purpose of this study was to compare the effects between midazolam and buprenorphine in postoperative patient controlled epidural analgesia. Forty patients aged 30 to 70 years with ASA physical status I or II for gastrectomy were enrolled. After insertion of an epidural catheter, general anesthesia was induced with thiopental, fentanyl, and vecuronium, and maintained with sevoflurane, nitrous oxide in oxygen with intermittent epidural injection of 1.5% lidocaine. At the end of surgery, 0.25% bupivacaine 5 mL + midazolam 3 mg (Midazolam group) or + buprenorphine 0.1 mg (Buprenorphine group) was epidurally injected followed by continuous epidural infusion at 3.3 mL/h for 24 hours with patient controlled analgesia (PCA) of 3 mL (lock out time of 30 minutes). The contents of the infuser were 0.25% bupivacaine 38 mL + midazolam 10 mg (Midazolam group) or 0.25% bupivacaine 39 mL + buprenorphine 0.2 mg (Buprenorphine group) for 12 hours and continued for 24 hours. Intramuscular pentazocine 15 mg was the rescue after PCA. Blood pressure, heart rate, respiratory rate, percutaneous oxygen pressure (SpO2), visual analog score (VAS) for pain, sedation level, the number of the PCA and pentazocine usage, and nausea and vomiting were monitored for postoperative 24 hours. All parameters measured were not different between the two groups. From these results, epidural PCA with midazolam had similar effects with buprenorphine when used for postoperative analgesia in gastrectomy.

Keywords: Postoperative analgesia, epidural block, patient controlled, analgesia, midazolam, buprenorphine, gastrectomy.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT