Abstract
MORICANDIA ARVENSIS EXTRACT INHIBITS LIPID PEROXIDATION, ACETHYLCHOLINESTERASE ACTIVITY AS WELL AS MUTAGENICITY AND ROS PRODUCTION IN COLORECTAL CANCER CELLS

Ines Skandrani*, Ludovic Leloup, Kamel Ghedia and Leila Chekir Ghedira

ABSTRACT

In this study, we investigate the potential of Moricandia arvensis chloroform leaf extract on acethylcholinesterase (AChE) activity, lipid peroxidation and DNA mutagenicity. Scavenging effect of reactive oxygen species (ROS) production in colorectal cells (BE) was also determined. The study of the chemical part of our extract shows a chemical profile containing squalene and fatty acids. Concerning the biological activities, the tested extract at the lowest dose decreased the acethylcholinesterase activity by 68.45% and inhibited strongly the lipoperoxydation induced by methyl methanesulfonate. Furthermore, chloroform leaf extract enhanced a significant antioxidant activity reaching 100%, in colorectal cancer cell line. A significant inhibition of mutagenicity induced by methyl methanesulfonate (76.32%) as well as 2-aminoanthracene (91%) in TA104 tested strain was also showed. This is the first study that shows the chemical composition of chloroform leaf extract and especially for this plant and its biological activities argue for its probable utilization in therapeutic or pharmaceutical arsenal.

Keywords: ChlL extract; AChE; Lipid peroxidation; ROS; genotoxicity.


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