Abstract
EVALUATION OF APOPTOTIC ACTIVITY OF BANGLADESHI PLANTS EXTRACT

Prawej Ansari*, Mustafe Khalid Mohamed , Sanjeeda Sarmin Badhan, Md. Saiful Islam, Md. Niaz Hossain, Sabbir Anwar, Md. Mustarek Uddin Meemo

ABSTRACT

Objective: This study was carried out with four plants, Ixora nigricans, Neolamarckia cadamba, Dalbergia stipulacea and Hymendictyon excelsum, extract and was intended to investigate as well as compare their activity on physiological model by studying in vitro. Method: The in vitro cytotoxic or apoptosis study was made using Brine shrimp lethality a bio-assay method, most known, simple and reliable method in this field. Result: Results of this study were obtained by following graphical analysis and expressed as median lethal concentration (LC50). Among those plant sample the extract from Ixora nigrican was found with least value (LC50 = 44.7μg/ml) at 95% confidence limit it ranges from 43.94 to 45.52μg/ml, the lower the value of LC50, higher the toxicity. Conclusion: On the view point from this result, we can conclude by saying that the extracts we studied have some pharmacological property that can aid in the treatment of carcinoma. We need to identify the molecule that causing this effect and then we can move for clinical trial.

Keywords: Apoptosis, brine shrimp, I. nigrican, N. cadamba, median lethal concentration (LC50).


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