European Journal of Biomedical and Pharmaceutical Sciences

SALMONELLA TYPHIMURIUM INFECTIONS TREATMENT IN MICE USING MORINGA OLIFERA AQUEOUS LEAVES EXTRACT

*Bagudo A. I., Aliero A. A. and Abubakar S. Z.

ABSTRACT

Inhibitory activities of Moringa olifera leaves extract was investigated using mice. Mice were divided into 3 groups of 5 mice (n=15). Group A was neither infected nor treated with the extract and was used as control. Group B were orally challenged with 0.1 ml (3.0 x 104 CFU) of Salmonella Typhimurium and received no extract treatment and Group C mice were orally challenged with 0.1 ml (3.0 x 104 CFU) of Salmonella Typhimurium and were orally treated twice daily with 0.5 ml of extract containing 100 and 200 mg/kg body weight of the extract at 12 hours interval for six (6) days, respectively. The extract was found to be effective in the treatment of Salmonella infection as there was a significant association between the extract treatment and increase in Body weight and Food consumption in the infected and treated group (C). An indicative that Moringa olifera leaves contain bioactive compounds which could be a source of new drug for the treatment of diseases cause by Salmonella Typhimurium.

Keywords: Moringa olifera leaves, Salmonella Typhimurium.