Abstract
CURRENT UPDATE ON PRESENTATION, PATHOGENESIS AND PROGNOSTIC MARKER OF BULLOUS PEMPHIGOID: A REVIEW

Samar Khan*, Megha Jain, SMA Feroz and Sameera Khan

ABSTRACT

Over the centuries, blistering skin disorders have been described under a variety of terms, such as pemphigus, plyctainia, phlyzakion. However, it is only about 40 years since Lever (1956), based on distinctive clinical and histological features, recognized bullous pemphigoid as a distinct disorder within the large group of blistering disorders, including the pemphigus group. Bullous pemphigoid is uncommon autoimmune subepithelial blistering diseases that most frequently arise in older adults and are characterized by the presence of cutaneous bullae and erosive mucosal lesions. Over the past few years due to advancement of markers and microscopes significant progress has been made in understanding the underlying pathogenesis of these diseases. Several factors including immunoglobulins, complement system and the migration of inflammatory cells into the subepithelial tissue, likely contribute to the clinical manifestations of bullous pemphigoid. This review will aid in understanding current concepts involved in presentation, pathogenesis, prognostic markers, diagnosis and treatment modalities bullous pemphigoid.

Keywords: Autoimmunity, Bullous pemphigoid, BP180, BP230, Hemidesmosome.


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