Abstract
SYNTHESIS AND MODE OF ACTION OF TRICYCLIC ANTIDEPRESSANTS

D.K. Awasthi* and Gynendra Awasthi

ABSTRACT

Depression is now common problem in human being. Antidepressive drugs are used to elevate the mood in depressive illness. All antidepressants affect, monoaminergic transmission in the brain mainly two types are antidepressant drugs which are tricycle Antidepressants and Monoamine oxidase inhibitors. They inhibits monoamine uptake and interact with a variety of receptors such as muscarine, histamine H1 and α-adrenergic,5- hydroxytryptamine 1 and 2 and occasionally with dopamine D2.TCAS and related drugs inhibit active uptake of biogenic amines. Tricyclic Antidepressantsareimipramine, Amitriptyline, Doxepin, Dothepin Clomipramieandadrenalineinhibitorsas Desipramine, Notriptyline, amoxapine.

Keywords: Depression Tricyclic Antidepressantsareimipramine, Amitriptyline, amoxapine.


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