TICKLING OF CELLULAR REDOX STATUS: A NOVEL STRATEGY TO DEVELOP POTENT RADIOPROTECTIVE AND ANTI-INFLAMMATORY AGENTS
Dr. Lokesh Gambhir*
ABSTRACT
Multiple strategies have been investigated to develop novel radioprotectors. But none of them have been approved by FDA as putative agent outside clinic. Thus, a dire need exists to postulate a new strategy that can yield a spectrum of novel compounds with potential to ameliorate radiation insult. Since, inflammation mediates the pathogenesis of radiation injury, a putative agent which is able to elicit anti-inflammatory and cytoprotective response in the cell shall be a putative agent. Cellular redox homeostasis is essential for maintaining viability and normal physiological functions of cell. To maintain the redox balance cells are equipped with a network of antioxidant enzymes that can detoxify the induced oxidative stress. The present review highlights the perturbation of cellular redox status by employing redox modifiers like prooxidants as an amenable strategy for developing novel radioprotectors and anti-inflammatory agents. Prooxidants lead to the activation of redox sensitive immunoregulatory and cytoprotective transcription factor Nrf2. Activation of Nrf2 leads to production of cytoprotective antioxidants to combat radiation induced oxidative damage, anti-inflammatory proteins and downregulation of NF-κB to combat inflammation.
Keywords: Nrf2, oxidative stress, radiation protection, NF-?B.
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